Differences in Smad4 expression in human papillomavirus type 16-positive and human papillomavirus type 16-negative head and neck squamous cell carcinoma.

@article{Bez2005DifferencesIS,
  title={Differences in Smad4 expression in human papillomavirus type 16-positive and human papillomavirus type 16-negative head and neck squamous cell carcinoma.},
  author={Adriana B{\'a}ez and Alan M Cantor and Sharon Fonseca and Mar{\'i}a J. Marcos-Mart{\'i}nez and Linda A. Mathews and Carlos A. Muro-Cacho and Teresita Mu{\~n}oz-Antonia},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2005},
  volume={11 9},
  pages={3191-7}
}
The SMADs are a group of interrelated proteins that mediate transforming growth factor beta (TGF-beta) signaling. Upon TGF-beta binding the TGF-beta type I receptor phosphorylates Smad2 and Smad3, which then complex with Smad4 and translocate to the nucleus, with subsequent activation of target genes. Disruption of TGF-beta signaling is thought to… CONTINUE READING