Differences in Rat Dorsal Striatal NMDA and AMPA Receptors following Acute and Repeated Cocaine-Induced Locomotor Activation

@inproceedings{Yamamoto2012DifferencesIR,
  title={Differences in Rat Dorsal Striatal NMDA and AMPA Receptors following Acute and Repeated Cocaine-Induced Locomotor Activation},
  author={D Yamamoto and Nancy R. Zahniser},
  booktitle={PloS one},
  year={2012}
}
Sprague-Dawley rats can be classified as low or high cocaine responders (LCRs or HCRs, respectively) based on their locomotor activity induced by an acute low dose of cocaine. Upon repeated cocaine exposure, LCRs display greater locomotor sensitization, reward, and reinforcement than HCRs. Altered glutamate receptor expression in the brain reward pathway has been linked to locomotor sensitization and addiction. To determine if such changes contribute to the differential development of locomotor… CONTINUE READING

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