Differences in PLP-Dependent Cysteinyl Processing Lead to Diverse S-Functionalization of Lincosamide Antibiotics.

@article{Wang2016DifferencesIP,
  title={Differences in PLP-Dependent Cysteinyl Processing Lead to Diverse S-Functionalization of Lincosamide Antibiotics.},
  author={Min Wang and Qunfei Zhao and Qinglin Zhang and Wen Liu},
  journal={Journal of the American Chemical Society},
  year={2016},
  volume={138 20},
  pages={
          6348-51
        }
}
Pyridoxal-5'-phosphate (PLP)-dependent proteins constitute one of the largest and most important families of enzymes in living organisms. These proteins participate in numerous biochemical processes, many of which have not been characterized, and transform substrates containing an amino group through various reactions that share aldimine as a common intermediate. Herein, we report that the PLP-dependent enzymes CcbF and LmbF, which are highly related in phylogenesis, process cysteine S… CONTINUE READING
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Antimicrob. Agents Chemother

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