Differences in N-glycan structures found on recombinant IgA1 and IgA2 produced in murine myeloma and CHO cell lines.

@article{Yoo2010DifferencesIN,
  title={Differences in N-glycan structures found on recombinant IgA1 and IgA2 produced in murine myeloma and CHO cell lines.},
  author={Esther M. Yoo and Li Jun Yu and Letitia A. Wims and David Goldberg and Sherie L. Morrison},
  journal={mAbs},
  year={2010},
  volume={2 3},
  pages={
          320-34
        }
}
The development and production of recombinant monoclonal antibodies is well established. Although most of these are IgGs, there is also great interest in producing recombinant IgAs since this isotype plays a critical role in providing immunologic protection at mucosal surfaces. The choice of expression system for production of recombinant antibodies is crucial because they are glycoproteins containing at least one N-linked carbohydrate. These glycans have been shown to contribute to the… CONTINUE READING
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