Differences in Lipoprotein Lipid Concentration and Composition Modify the Plasma Distribution of Cyclosporine

@article{Wasan1997DifferencesIL,
  title={Differences in Lipoprotein Lipid Concentration and Composition Modify the Plasma Distribution of Cyclosporine},
  author={Kishor M. Wasan and Parmely H Pritchard and Manisha Ramaswamy and Wesley Wong and Elizabeth Mary Donnachie and Lane J. Brunner},
  journal={Pharmaceutical Research},
  year={1997},
  volume={14},
  pages={1613-1620}
}
AbstractPurpose. The purpose of this study was to define the relationship between lipoprotein (LP) lipid concentration and composition and the distribution of cyclosporine (CSA) in human plasma. Methods. 3H-CSA LP distribution was determined in normolipidemic human plasma that had been separated into different LP and lipoprotein-deficient plasma (LPDP) fractions by either affinity chromatography coupled with ultracentrifugation, density gradient ultracentrifugation or fast protein liquid… CONTINUE READING

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