Corpus ID: 29497413

Differences in IL-4 release by PBMC are related with heterogeneity of atopy.

  title={Differences in IL-4 release by PBMC are related with heterogeneity of atopy.},
  author={J. P{\`e}ne and A. Rivier and B. Lagier and W. Becker and F. Michel and J. Bousquet},
  volume={81 1},
  • J. Pène, A. Rivier, +3 authors J. Bousquet
  • Published 1994
  • Medicine
  • Immunology
  • Atopy is heterogeneous and the IgE immune response of patients allergic to a single allergen (monosensitized) differs from that of those allergic to multiple allergens (polysensitized). Since interleukin-4 (IL-4) and interferon-gamma (IFN-gamma) regulate human IgE synthesis in vitro, we determined whether cytokines may be involved in the heterogeneity of atopy by comparing the serum IgE and sCD23 titres to the cytokine profile of T lymphocytes from 44 atopic patients (13 mono- and 31… CONTINUE READING
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