Differences in HIV-1 pol sequences from female genital tract and blood during antiretroviral therapy.

@article{Pasquale2003DifferencesIH,
  title={Differences in HIV-1 pol sequences from female genital tract and blood during antiretroviral therapy.},
  author={Maria Pia De Pasquale and Andrew J. Leigh Brown and Susan Cu Uvin and Jessica Allega-Ingersoll and Angela M. Caliendo and Lorraine Sutton and Shannon E. Donahue and R. T. D'Aquila},
  journal={Journal of acquired immune deficiency syndromes},
  year={2003},
  volume={34 1},
  pages={37-44}
}
OBJECTIVE To determine whether HIV-1 replicates locally in the female genital tract during therapy, and to study whether endocervix is the dominant source of virus in cervicovaginal lavage fluid. DESIGN Sequence analyses of HIV-1 pol were performed from cervicovaginal secretions and blood plasma of HIV-infected women failing antiretroviral therapy with detectable viral load in both compartments, as well as from drug-naive subjects. METHODS Viral RNA was extracted from cervicovaginal lavage… CONTINUE READING
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