Differences in FMO2*1 allelic frequency between Hispanics of Puerto Rican and Mexican descent.

  title={Differences in FMO2*1 allelic frequency between Hispanics of Puerto Rican and Mexican descent.},
  author={Sharon K. Krueger and Lisbeth K. Siddens and Sarah R Martin and Zhen Yu and Clifford B Pereira and Erwin T. Cabacungan and Ronald N Hines and Kristin G. Ardlie and Judy L. Raucy and David Edward Williams},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  volume={32 12},
A polymorphism for the phase I drug-metabolizing enzyme, flavin-containing monooxygenase isoform 2 (FMO2), encoding either truncated inactive protein, FMO2X472 (FMO2.2A), or full-length active enzyme, FMO2Q472 (FMO2.1), is known and exhibits significant interethnic differences in allelic frequency. FMO2 is the major or sole FMO isoform expressed in the lung of most mammals, including nonhuman primates. To date, FMO2.1 has been found only in African-American and Hispanic populations, rendering… CONTINUE READING
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An overview of the mechanism, substrate specificities and structure of FMOs

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  • Drug Metab Rev 34:503–511
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Identification of novel variants of the flavin - containing monooxygenase gene family in African Americans

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  • Drug Metab Dispos
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