Differences in DNA methylation profile of Th1 and Th2 cytokine genes are associated with tolerance acquisition in children with IgE-mediated cow’s milk allergy

Abstract

Epigenetic changes in DNA methylation could regulate the expression of several allergy-related genes. We investigated whether tolerance acquisition in children with immunoglobulin E (IgE)-mediated cow’s milk allergy (CMA) is characterized by a specific DNA methylation profile of Th2 (IL-4, IL-5) and Th1 (IL-10, IFN-γ)-associated cytokine genes. DNA… (More)
DOI: 10.1186/s13148-015-0070-8

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@inproceedings{Canani2015DifferencesID, title={Differences in DNA methylation profile of Th1 and Th2 cytokine genes are associated with tolerance acquisition in children with IgE-mediated cow’s milk allergy}, author={R Berni Canani and L Paparo and R Nocerino and Linda Cosenza and Vincenza Pezzella and Margherita di Costanzo and Mario Capasso and Valentina Del Monaco and Valeria D’Argenio and Luigi Greco and Francesco Salvatore}, booktitle={Clinical Epigenetics}, year={2015} }