Differences in Clinical Characteristics between Patients with Endoscopy-Negative Reflux Disease and Erosive Esophagitis in Japan

@article{Fujiwara2005DifferencesIC,
  title={Differences in Clinical Characteristics between Patients with Endoscopy-Negative Reflux Disease and Erosive Esophagitis in Japan},
  author={Yasuhiro Fujiwara and Kazuhide Higuchi and Masatsugu Shiba and Kazuki Yamamori and Yoko Watanabe and Eiji Sasaki and K Tominaga and Toshio Watanabe and Nobuhide Oshitani and Tetsuo Arakawa},
  journal={The American Journal of Gastroenterology},
  year={2005},
  volume={100},
  pages={754-758}
}
OBJECTIVE:Helicobacter pylori infection and atrophic gastritis are inversely related to erosive esophagitis. Whether these factors affect the pathogenesis of endoscopy-negative reflux disease is not clear. We aimed to elucidate the differences in clinical characteristics between endoscopy-negative erosive disease and erosive esophagitis.METHODS:253 subjects (89 with endoscopy-negative reflux disease and 164 with erosive esophagitis) were studied. Gastric atrophy was assessed by measurement of… CONTINUE READING

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