Differences in Atherosclerotic Plaque Burden and Morphology Between Type 1 and 2 Diabetes as Assessed by Multislice Computed Tomography

@inproceedings{Djaberi2009DifferencesIA,
  title={Differences in Atherosclerotic Plaque Burden and Morphology Between Type 1 and 2 Diabetes as Assessed by Multislice Computed Tomography},
  author={Roxana Djaberi and Joanne D. Schuijf and Eric Boersma and Lucia J. M. Kroft and Alberto Martin Pereira and Johannes Anthonius Romijn and Arthur J. H. A. Scholte and J Wouter Jukema and Jeroen J. Bax},
  booktitle={Diabetes care},
  year={2009}
}
OBJECTIVE It is unclear whether the coronary atherosclerotic plaque burden is similar in patients with type 1 and type 2 diabetes. By using multislice computed tomography (MSCT), the presence, degree, and morphology of coronary artery disease (CAD) in patients with type 1 and type 2 diabetes were compared. RESEARCH DESIGN AND METHODS Prospectively, coronary artery calcium (CAC) scoring and MSCT coronary angiography were performed in 135 asymptomatic patients (65 patients with type 1 diabetes… CONTINUE READING

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RESEARCH DESIGN AND METHODS Prospectively , coronary artery calcium ( CAC ) scoring and MSCT coronary angiography were performed in 135 asymptomatic patients ( 65 patients with type 1 diabetes and 70 patients with type 2 diabetes ) .
However , the prevalence of obstructive atherosclerosis was higher in patients with type 2 diabetes ( n = 24 ; 34% ) compared with that in patients with type 1 diabetes ( n = 11 ; 17% ) ( P = 0.02 ) .
In addition , the percentage of noncalcified plaques was higher in patients with type 2 ( 66% ) versus type 1 diabetes ( 27% ) ( P < 0.001 ) , resulting in a higher plaque burden for each CAC score compared with that in type 1 diabetic patients .
RESEARCH DESIGN AND METHODS Prospectively , coronary artery calcium ( CAC ) scoring and MSCT coronary angiography were performed in 135 asymptomatic patients ( 65 patients with type 1 diabetes and 70 patients with type 2 diabetes ) .
However , the prevalence of obstructive atherosclerosis was higher in patients with type 2 diabetes ( n = 24 ; 34% ) compared with that in patients with type 1 diabetes ( n = 11 ; 17% ) ( P = 0.02 ) .
In addition , the percentage of noncalcified plaques was higher in patients with type 2 ( 66% ) versus type 1 diabetes ( 27% ) ( P < 0.001 ) , resulting in a higher plaque burden for each CAC score compared with that in type 1 diabetic patients .
RESEARCH DESIGN AND METHODS Prospectively , coronary artery calcium ( CAC ) scoring and MSCT coronary angiography were performed in 135 asymptomatic patients ( 65 patients with type 1 diabetes and 70 patients with type 2 diabetes ) .
However , the prevalence of obstructive atherosclerosis was higher in patients with type 2 diabetes ( n = 24 ; 34% ) compared with that in patients with type 1 diabetes ( n = 11 ; 17% ) ( P = 0.02 ) .
In addition , the percentage of noncalcified plaques was higher in patients with type 2 ( 66% ) versus type 1 diabetes ( 27% ) ( P < 0.001 ) , resulting in a higher plaque burden for each CAC score compared with that in type 1 diabetic patients .
RESEARCH DESIGN AND METHODS Prospectively , coronary artery calcium ( CAC ) scoring and MSCT coronary angiography were performed in 135 asymptomatic patients ( 65 patients with type 1 diabetes and 70 patients with type 2 diabetes ) .
However , the prevalence of obstructive atherosclerosis was higher in patients with type 2 diabetes ( n = 24 ; 34% ) compared with that in patients with type 1 diabetes ( n = 11 ; 17% ) ( P = 0.02 ) .
In addition , the percentage of noncalcified plaques was higher in patients with type 2 ( 66% ) versus type 1 diabetes ( 27% ) ( P < 0.001 ) , resulting in a higher plaque burden for each CAC score compared with that in type 1 diabetic patients .
In addition , the percentage of noncalcified plaques was higher in patients with type 2 ( 66% ) versus type 1 diabetes ( 27% ) ( P < 0.001 ) , resulting in a higher plaque burden for each CAC score compared with that in type 1 diabetic patients .
RESEARCH DESIGN AND METHODS Prospectively , coronary artery calcium ( CAC ) scoring and MSCT coronary angiography were performed in 135 asymptomatic patients ( 65 patients with type 1 diabetes and 70 patients with type 2 diabetes ) .
However , the prevalence of obstructive atherosclerosis was higher in patients with type 2 diabetes ( n = 24 ; 34% ) compared with that in patients with type 1 diabetes ( n = 11 ; 17% ) ( P = 0.02 ) .
RESEARCH DESIGN AND METHODS Prospectively , coronary artery calcium ( CAC ) scoring and MSCT coronary angiography were performed in 135 asymptomatic patients ( 65 patients with type 1 diabetes and 70 patients with type 2 diabetes ) .
However , the prevalence of obstructive atherosclerosis was higher in patients with type 2 diabetes ( n = 24 ; 34% ) compared with that in patients with type 1 diabetes ( n = 11 ; 17% ) ( P = 0.02 ) .
In addition , the percentage of noncalcified plaques was higher in patients with type 2 ( 66% ) versus type 1 diabetes ( 27% ) ( P < 0.001 ) , resulting in a higher plaque burden for each CAC score compared with that in type 1 diabetic patients .
In addition , the percentage of noncalcified plaques was higher in patients with type 2 ( 66% ) versus type 1 diabetes ( 27% ) ( P < 0.001 ) , resulting in a higher plaque burden for each CAC score compared with that in type 1 diabetic patients .
RESEARCH DESIGN AND METHODS Prospectively , coronary artery calcium ( CAC ) scoring and MSCT coronary angiography were performed in 135 asymptomatic patients ( 65 patients with type 1 diabetes and 70 patients with type 2 diabetes ) .
However , the prevalence of obstructive atherosclerosis was higher in patients with type 2 diabetes ( n = 24 ; 34% ) compared with that in patients with type 1 diabetes ( n = 11 ; 17% ) ( P = 0.02 ) .
However , the prevalence of obstructive atherosclerosis was higher in patients with type 2 diabetes ( n = 24 ; 34% ) compared with that in patients with type 1 diabetes ( n = 11 ; 17% ) ( P = 0.02 ) .
RESEARCH DESIGN AND METHODS Prospectively , coronary artery calcium ( CAC ) scoring and MSCT coronary angiography were performed in 135 asymptomatic patients ( 65 patients with type 1 diabetes and 70 patients with type 2 diabetes ) .
However , the prevalence of obstructive atherosclerosis was higher in patients with type 2 diabetes ( n = 24 ; 34% ) compared with that in patients with type 1 diabetes ( n = 11 ; 17% ) ( P = 0.02 ) .
RESEARCH DESIGN AND METHODS Prospectively , coronary artery calcium ( CAC ) scoring and MSCT coronary angiography were performed in 135 asymptomatic patients ( 65 patients with type 1 diabetes and 70 patients with type 2 diabetes ) .
However , the prevalence of obstructive atherosclerosis was higher in patients with type 2 diabetes ( n = 24 ; 34% ) compared with that in patients with type 1 diabetes ( n = 11 ; 17% ) ( P = 0.02 ) .
RESEARCH DESIGN AND METHODS Prospectively , coronary artery calcium ( CAC ) scoring and MSCT coronary angiography were performed in 135 asymptomatic patients ( 65 patients with type 1 diabetes and 70 patients with type 2 diabetes ) .
However , the prevalence of obstructive atherosclerosis was higher in patients with type 2 diabetes ( n = 24 ; 34% ) compared with that in patients with type 1 diabetes ( n = 11 ; 17% ) ( P = 0.02 ) .
RESEARCH DESIGN AND METHODS Prospectively , coronary artery calcium ( CAC ) scoring and MSCT coronary angiography were performed in 135 asymptomatic patients ( 65 patients with type 1 diabetes and 70 patients with type 2 diabetes ) .
However , the prevalence of obstructive atherosclerosis was higher in patients with type 2 diabetes ( n = 24 ; 34% ) compared with that in patients with type 1 diabetes ( n = 11 ; 17% ) ( P = 0.02 ) .
RESEARCH DESIGN AND METHODS Prospectively , coronary artery calcium ( CAC ) scoring and MSCT coronary angiography were performed in 135 asymptomatic patients ( 65 patients with type 1 diabetes and 70 patients with type 2 diabetes ) .
However , the prevalence of obstructive atherosclerosis was higher in patients with type 2 diabetes ( n = 24 ; 34% ) compared with that in patients with type 1 diabetes ( n = 11 ; 17% ) ( P = 0.02 ) .
RESEARCH DESIGN AND METHODS Prospectively , coronary artery calcium ( CAC ) scoring and MSCT coronary angiography were performed in 135 asymptomatic patients ( 65 patients with type 1 diabetes and 70 patients with type 2 diabetes ) .
However , the prevalence of obstructive atherosclerosis was higher in patients with type 2 diabetes ( n = 24 ; 34% ) compared with that in patients with type 1 diabetes ( n = 11 ; 17% ) ( P = 0.02 ) .
RESEARCH DESIGN AND METHODS Prospectively , coronary artery calcium ( CAC ) scoring and MSCT coronary angiography were performed in 135 asymptomatic patients ( 65 patients with type 1 diabetes and 70 patients with type 2 diabetes ) .
By using multislice computed tomography ( MSCT ) , the presence , degree , and morphology of coronary artery disease ( CAD ) in patients with type 1 and type 2 diabetes were compared .
By using multislice computed tomography ( MSCT ) , the presence , degree , and morphology of coronary artery disease ( CAD ) in patients with type 1 and type 2 diabetes were compared .
In addition , the percentage of noncalcified plaques was higher in patients with type 2 ( 66% ) versus type 1 diabetes ( 27% ) ( P < 0.001 ) , resulting in a higher plaque burden for each CAC score compared with that in type 1 diabetic patients .
RESEARCH DESIGN AND METHODS Prospectively , coronary artery calcium ( CAC ) scoring and MSCT coronary angiography were performed in 135 asymptomatic patients ( 65 patients with type 1 diabetes and 70 patients with type 2 diabetes ) .
However , the prevalence of obstructive atherosclerosis was higher in patients with type 2 diabetes ( n = 24 ; 34% ) compared with that in patients with type 1 diabetes ( n = 11 ; 17% ) ( P = 0.02 ) .
In addition , the percentage of noncalcified plaques was higher in patients with type 2 ( 66% ) versus type 1 diabetes ( 27% ) ( P < 0.001 ) , resulting in a higher plaque burden for each CAC score compared with that in type 1 diabetic patients .
RESEARCH DESIGN AND METHODS Prospectively , coronary artery calcium ( CAC ) scoring and MSCT coronary angiography were performed in 135 asymptomatic patients ( 65 patients with type 1 diabetes and 70 patients with type 2 diabetes ) .
However , the prevalence of obstructive atherosclerosis was higher in patients with type 2 diabetes ( n = 24 ; 34% ) compared with that in patients with type 1 diabetes ( n = 11 ; 17% ) ( P = 0.02 ) .
In addition , the percentage of noncalcified plaques was higher in patients with type 2 ( 66% ) versus type 1 diabetes ( 27% ) ( P < 0.001 ) , resulting in a higher plaque burden for each CAC score compared with that in type 1 diabetic patients .
RESEARCH DESIGN AND METHODS Prospectively , coronary artery calcium ( CAC ) scoring and MSCT coronary angiography were performed in 135 asymptomatic patients ( 65 patients with type 1 diabetes and 70 patients with type 2 diabetes ) .
However , the prevalence of obstructive atherosclerosis was higher in patients with type 2 diabetes ( n = 24 ; 34% ) compared with that in patients with type 1 diabetes ( n = 11 ; 17% ) ( P = 0.02 ) .
RESEARCH DESIGN AND METHODS Prospectively , coronary artery calcium ( CAC ) scoring and MSCT coronary angiography were performed in 135 asymptomatic patients ( 65 patients with type 1 diabetes and 70 patients with type 2 diabetes ) .
However , the prevalence of obstructive atherosclerosis was higher in patients with type 2 diabetes ( n = 24 ; 34% ) compared with that in patients with type 1 diabetes ( n = 11 ; 17% ) ( P = 0.02 ) .
RESEARCH DESIGN AND METHODS Prospectively , coronary artery calcium ( CAC ) scoring and MSCT coronary angiography were performed in 135 asymptomatic patients ( 65 patients with type 1 diabetes and 70 patients with type 2 diabetes ) .
However , the prevalence of obstructive atherosclerosis was higher in patients with type 2 diabetes ( n = 24 ; 34% ) compared with that in patients with type 1 diabetes ( n = 11 ; 17% ) ( P = 0.02 ) .
However , the prevalence of obstructive atherosclerosis was higher in patients with type 2 diabetes ( n = 24 ; 34% ) compared with that in patients with type 1 diabetes ( n = 11 ; 17% ) ( P = 0.02 ) .
RESEARCH DESIGN AND METHODS Prospectively , coronary artery calcium ( CAC ) scoring and MSCT coronary angiography were performed in 135 asymptomatic patients ( 65 patients with type 1 diabetes and 70 patients with type 2 diabetes ) .
However , the prevalence of obstructive atherosclerosis was higher in patients with type 2 diabetes ( n = 24 ; 34% ) compared with that in patients with type 1 diabetes ( n = 11 ; 17% ) ( P = 0.02 ) .
RESEARCH DESIGN AND METHODS Prospectively , coronary artery calcium ( CAC ) scoring and MSCT coronary angiography were performed in 135 asymptomatic patients ( 65 patients with type 1 diabetes and 70 patients with type 2 diabetes ) .
However , the prevalence of obstructive atherosclerosis was higher in patients with type 2 diabetes ( n = 24 ; 34% ) compared with that in patients with type 1 diabetes ( n = 11 ; 17% ) ( P = 0.02 ) .
RESEARCH DESIGN AND METHODS Prospectively , coronary artery calcium ( CAC ) scoring and MSCT coronary angiography were performed in 135 asymptomatic patients ( 65 patients with type 1 diabetes and 70 patients with type 2 diabetes ) .
However , the prevalence of obstructive atherosclerosis was higher in patients with type 2 diabetes ( n = 24 ; 34% ) compared with that in patients with type 1 diabetes ( n = 11 ; 17% ) ( P = 0.02 ) .
RESEARCH DESIGN AND METHODS Prospectively , coronary artery calcium ( CAC ) scoring and MSCT coronary angiography were performed in 135 asymptomatic patients ( 65 patients with type 1 diabetes and 70 patients with type 2 diabetes ) .
However , the prevalence of obstructive atherosclerosis was higher in patients with type 2 diabetes ( n = 24 ; 34% ) compared with that in patients with type 1 diabetes ( n = 11 ; 17% ) ( P = 0.02 ) .
RESEARCH DESIGN AND METHODS Prospectively , coronary artery calcium ( CAC ) scoring and MSCT coronary angiography were performed in 135 asymptomatic patients ( 65 patients with type 1 diabetes and 70 patients with type 2 diabetes ) .
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