Differences in AMPA and kainate receptor interactomes facilitate identification of AMPA receptor auxiliary subunit GSG1L.

@article{Shanks2012DifferencesIA,
  title={Differences in AMPA and kainate receptor interactomes facilitate identification of AMPA receptor auxiliary subunit GSG1L.},
  author={Natalie F. Shanks and Jeffrey N Savas and Tomohiko Maruo and Ondrej Cais and Atsushi Hirao and Souichi Oe and Anirvan Ghosh and Yasuko Noda and Ingo H Greger and John R. Yates and Terunaga Nakagawa},
  journal={Cell reports},
  year={2012},
  volume={1 6},
  pages={590-8}
}
AMPA receptor (AMPA-R) complexes consist of channel-forming subunits, GluA1-4, and auxiliary proteins, including TARPs, CNIHs, synDIG1, and CKAMP44, which can modulate AMPA-R function in specific ways. The combinatorial effects of four GluA subunits binding to various auxiliary subunits amplify the functional diversity of AMPA-Rs. The significance and magnitude of molecular diversity, however, remain elusive. To gain insight into the molecular complexity of AMPA and kainate receptors, we… CONTINUE READING
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