Differences between the bisphosphonates for the prevention and treatment of osteoporosis

@article{Grey2006DifferencesBT,
  title={Differences between the bisphosphonates for the prevention and treatment of osteoporosis},
  author={A D N J de Grey and Ian R Reid},
  journal={Therapeutics and Clinical Risk Management},
  year={2006},
  volume={2},
  pages={77 - 86}
}
Bisphosphonates, pyrophosphate analogs which potently inhibit osteoclastic bone resorption, are now firmly established as first-line therapy for osteoporosis. Several bisphosphonates of varying antiresorptive potency are either in clinical use or well advanced in clinical trials. Alendronate and risedronate are agents of choice at present because data from randomized controlled trials demonstrate that each of these nitrogen (N)-containing-bisphosphonates reduces the incidence of vertebral and… CONTINUE READING
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