Differences between the antinociceptive effects of the cholinergic channel activators A-85380 and (+/-)-epibatidine in rats.

@article{Curzon1998DifferencesBT,
  title={Differences between the antinociceptive effects of the cholinergic channel activators A-85380 and (+/-)-epibatidine in rats.},
  author={Peter Curzon and Arthur L Nikkel and Anthony Bannon and Stephen Arneric and Michael W. Decker},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1998},
  volume={287 3},
  pages={847-53}
}
(+/-)-Epibatidine (EPIB) and A-85380 are nicotinic acetylcholine receptor (nAChR) agonists that bind to the agonist ([3H]cytisine) binding site with 40 to 50 pM affinity but have different affinities in nAChR subtype selective functional receptor assays. In vivo EPIB was more (23-fold) potent than A-85380 in reducing open field activity and more (12-fold) potent in reducing nociception in the formalin test of persistent chemical pain. In the rat hot box test of thermal acute pain, both… CONTINUE READING
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