Differences between rat liver epithelial cells and fibroblast cells in sensitivity to 8-azaguanine


Epithelial and fibroblast cells from adult rat liver were found to differ markedly in their sensitivities to the toxic effects of the purine analog, 8-azaguanine. Epithelial cells were rapidly killed by 8-azaguanine, whereas fibroblast cells suffered no observable toxicity. The resistance of fibroblast cells was not due to impermeability since it was shown… (More)
DOI: 10.1007/BF02619195

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