Differences between orofacial inflammation and cancer pain.

  title={Differences between orofacial inflammation and cancer pain.},
  author={Nozomu Harano and Kentaro Ono and Kiyoshi Hidaka and Aya Kai and Osamu Nakanishi and Kiyotoshi Inenaga},
  journal={Journal of dental research},
  volume={89 6},
Rat models of orofacial cancer exhibit both allodynia and hyperalgesia; however, it is unclear whether cancer-induced pain is secondary to cancer-induced inflammation. To address this question, we compared the effects of an anti-inflammatory drug, indomethacin, on pain and neurochemical changes in the medullary dorsal horn in orofacial inflammation and cancer models. Daily peripheral administration of indomethacin largely suppressed mechanical allodynia and thermal hyperalgesia in the… CONTINUE READING