Differences between magnetoencephalographic (MEG) spectral profiles of drugs acting on GABA at synaptic and extrasynaptic sites: A study in healthy volunteers

@article{Nutt2015DifferencesBM,
  title={Differences between magnetoencephalographic (MEG) spectral profiles of drugs acting on GABA at synaptic and extrasynaptic sites: A study in healthy volunteers},
  author={David Nutt and Sue Wilson and Anne Lingford-Hughes and Jim F. M. Myers and Andreas Papadopoulos and Suresh D. Muthukumaraswamy},
  journal={Neuropharmacology},
  year={2015},
  volume={88},
  pages={155-163}
}
A range of medications target different aspects of the GABA system; understanding their effects is important to inform further drug development. Effects on the waking EEG comparing these mechanisms have not been reported; in this study we compare the effects on resting MEG spectra of the benzodiazepine receptor agonist zolpidem, the delta sub-unit selective agonist gaboxadol (also known as THIP) and the GABA reuptake inhibitor tiagabine. These were two randomised, single-blind, placebo… CONTINUE READING

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