Differences between germline genomes of monozygotic twins

@article{Jnsson2021DifferencesBG,
  title={Differences between germline genomes of monozygotic twins},
  author={H{\'a}kon J{\'o}nsson and Erna Magn{\'u}sd{\'o}ttir and Hannes P. Eggertsson and Olafur A Stefansson and Gudny A. Arnadottir and Ogmundur Eiriksson and Florian Zink and Einar A Helgason and Ingileif J{\'o}nsd{\'o}ttir and Arnaldur Gylfason and Adalbjorg Jonasdottir and {\'A}slaug J{\'o}nasd{\'o}ttir and Doruk Beyter and Thora Steingrimsdottir and Gudmundur L. Norddahl and Olafur T Magnusson and G{\'i}sli M{\'a}sson and Bjarni V. Halld{\'o}rsson and Unnur Thorsteinsd{\'o}ttir and Agnar Helgason and Patrick Sulem and Daniel Fannar Gudbjartsson and K{\'a}ri Stef{\'a}nsson},
  journal={Nature Genetics},
  year={2021},
  volume={53},
  pages={27-34}
}
Despite the important role that monozygotic twins have played in genetics research, little is known about their genomic differences. Here we show that monozygotic twins differ on average by 5.2 early developmental mutations and that approximately 15% of monozygotic twins have a substantial number of these early developmental mutations specific to one of them. Using the parents and offspring of twins, we identified pre-twinning mutations. We observed instances where a twin was formed from a… 

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