Differences between germline genomes of monozygotic twins

@article{Jnsson2021DifferencesBG,
  title={Differences between germline genomes of monozygotic twins},
  author={H. J{\'o}nsson and Erna Magn{\'u}sd{\'o}ttir and Hannes P. Eggertsson and Olafur A Stefansson and G. Arnadottir and O. Eiriksson and F. Zink and Einar A Helgason and I. J{\'o}nsd{\'o}ttir and A. Gylfason and Adalbjorg Jonasdottir and A. Jonasdottir and Doruk Beyter and T. Steingrimsdottir and G. Norddahl and O. Magnusson and G. M{\'a}sson and B. Halld{\'o}rsson and U. Thorsteinsdottir and Agnar Helgason and P. Sulem and D. Gudbjartsson and K. Stef{\'a}nsson},
  journal={Nature Genetics},
  year={2021},
  volume={53},
  pages={27-34}
}
Despite the important role that monozygotic twins have played in genetics research, little is known about their genomic differences. Here we show that monozygotic twins differ on average by 5.2 early developmental mutations and that approximately 15% of monozygotic twins have a substantial number of these early developmental mutations specific to one of them. Using the parents and offspring of twins, we identified pre-twinning mutations. We observed instances where a twin was formed from a… Expand

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References

SHOWING 1-10 OF 35 REFERENCES
Timing, rates and spectra of human germline mutation
Mutation rates and the evolution of germline structure
  • A. Scally
  • Biology, Medicine
  • Philosophical Transactions of the Royal Society B: Biological Sciences
  • 2016
Parental somatic mosaicism is underrecognized and influences recurrence risk of genomic disorders.
Multiple transmissions of de novo mutations in families
...
1
2
3
4
...