Differences between and combinations of opioids re-visited

  title={Differences between and combinations of opioids re-visited},
  author={M. Smith},
  journal={Current Opinion in Anaesthesiology},
  • M. Smith
  • Published 2008
  • Medicine
  • Current Opinion in Anaesthesiology
  • Purpose of review Recent studies highlighting between-opioid differences in patient outcomes, opioid receptor interactions and animal study findings implicating a ‘fine control’ mechanism underpinning potential diversity in opioid receptor signalling that could potentially be exploited to develop novel opioid analgesics with improved tolerability are reviewed. Recent findings Recent clinical trials confirm the success of ‘opioid rotation’ for improving opioid tolerability and restoring… CONTINUE READING
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