Differences between alcohol-preferring and alcohol-nonpreferring rats in ethanol generalization.

@article{Mcmillan1999DifferencesBA,
  title={Differences between alcohol-preferring and alcohol-nonpreferring rats in ethanol generalization.},
  author={D. E. Mcmillan and Mi Li and D J Shide},
  journal={Pharmacology, biochemistry, and behavior},
  year={1999},
  volume={64 2},
  pages={415-9}
}
Alcohol-preferring (P rats) and alcohol-nonpreferring rats (NP rats) were trained to discriminate intraperitoneal injections of 0.5 g/kg ethanol, or subcutaneous injections of 0.6 mg/kg nicotine from saline. P rats learned the ethanol discrimination more rapidly and made a higher percentage (88%) of their responses on the ethanol lever after ethanol and a lower percentage (7%) after saline than NP rats (78 and 15%, respectively). In substitution tests, increasing doses of ethanol produced… CONTINUE READING