Differences between accumbens core and shell neurons exhibiting phasic firing patterns related to drug-seeking behavior during a discriminative-stimulus task.

@article{Ghitza2004DifferencesBA,
  title={Differences between accumbens core and shell neurons exhibiting phasic firing patterns related to drug-seeking behavior during a discriminative-stimulus task.},
  author={Udi E. Ghitza and Anthony T. Fabbricatore and Volodymyr F Prokopenko and Mark O. West},
  journal={Journal of neurophysiology},
  year={2004},
  volume={92 3},
  pages={1608-14}
}
The habit-forming effects of abused drugs depend on the mesocorticolimbic dopamine system innervating the nucleus accumbens (NAcc). To examine whether different NAcc subterritories (core and medial shell) exhibit a differential distribution of neurons showing phasic firing patterns correlated with drug-seeking behavior, rats were trained to self-administer cocaine, and activity of single NAcc neurons was recorded. In the presence of a discriminative-stimulus (S(D)) tone, a single lever press… CONTINUE READING

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The rat brain in stereotaxic coordinates (3rd edition)

  • G Paxinos, C. Watson
  • New York: Academic Press Inc,
  • 1997
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