Differences between Human Plasma and Serum Metabolite Profiles

  title={Differences between Human Plasma and Serum Metabolite Profiles},
  author={Zhonghao Yu and Gabi Kastenm{\"u}ller and Ying He and Petra Belcredi and Gabriele Moeller and Cornelia Prehn and Joaquim Mendes and Simone Wahl and Werner Roemisch-Margl and Uta Ceglarek and Alexey Polonikov and Norbert Dahmen and Holger Prokisch and Lu Xie and Yixue Li and H. -Erich Wichmann and Annette Peters and Florian Kronenberg and Karsten Suhre and Jerzy Adamski and Thomas Illig and Rui Wang-Sattler},
  booktitle={PloS one},
BACKGROUND Human plasma and serum are widely used matrices in clinical and biological studies. However, different collecting procedures and the coagulation cascade influence concentrations of both proteins and metabolites in these matrices. The effects on metabolite concentration profiles have not been fully characterized. METHODOLOGY/PRINCIPAL FINDINGS We analyzed the concentrations of 163 metabolites in plasma and serum samples collected simultaneously from 377 fasting individuals. To… CONTINUE READING
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