Differences between A 68930 and SKF 82958 could suggest synergistic roles of D1 and D5 receptors

@article{Nergrdh2005DifferencesBA,
  title={Differences between A 68930 and SKF 82958 could suggest synergistic roles of D1 and D5 receptors},
  author={R. Nerg{\aa}rdh and S. Oerther and B. Fredholm},
  journal={Pharmacology Biochemistry and Behavior},
  year={2005},
  volume={82},
  pages={495-505}
}
  • R. Nergårdh, S. Oerther, B. Fredholm
  • Published 2005
  • Medicine, Psychology
  • Pharmacology Biochemistry and Behavior
  • The isochroman A 68930 and the benzazepine SKF 82958 are two full dopamine D1 receptor agonists. Responses to these compounds are different in several important aspects. When given to rats in a novel environment, A 68930 caused a dose-dependent (0.019-4.9 mg/kg) suppression of locomotion. SKF 82958 had no such effect at any dose studied (0.051-3.3 mg/kg). In animals habituated to the environment, A 68930 had no effect but SKF 82958 increased locomotor activity. Both A 68930 and SKF 82958 caused… CONTINUE READING
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