Differences between 5‐HT3 receptor antagonists in modulation of visceral hypersensitivity

@article{Banner1995DifferencesB5,
  title={Differences between 5‐HT3 receptor antagonists in modulation of visceral hypersensitivity},
  author={Sheryl Banner and Gareth J. Sanger},
  journal={British Journal of Pharmacology},
  year={1995},
  volume={114}
}
1 Noxious colo‐rectal distension was applied in conscious rats by acute balloon inflation and the effects observed as abdominal muscle contraction with the threshold typically between 10–40 mmHg. The effects of 5‐HT3 receptor antagonists on responses to noxious colo‐rectal distension were then studied in both normal rats and those pretreated with 5‐hydroxytryptophan (5‐HTP). 2 Granisetron and ondansetron (10 μg kg−1 and 1 mg kg−1, s.c.) had no effect on visceromotor thresholds to colo‐rectal… Expand
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