Differences and evolution of the methods for the assessment of microsatellite instability

@article{Laghi2008DifferencesAE,
  title={Differences and evolution of the methods for the assessment of microsatellite instability},
  author={Luigi Laghi and Paolo Bianchi and Alberto Malesci},
  journal={Oncogene},
  year={2008},
  volume={27},
  pages={6313-6321}
}
Microsatellite instability (MSI) originates from the systematic accumulation of uncorrected deletion/insertion in repetitive DNA tracts in cancer cells with a deficient mismatch repair system. Among colorectal cancers, the MSI signature identifies hereditary cases arising in patients with germline mutations in hMLH1, hMSH2, PMS2 and a fraction of those with hMSH6 mutations, as well as sporadic cancers with epigenetic hMLH1 promoter hypermethylation. Considering the specific pathogenesis… CONTINUE READING

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