Differences and Similarities in TRAIL- and Tumor Necrosis Factor-Mediated Necroptotic Signaling in Cancer Cells.

@article{Sosna2016DifferencesAS,
  title={Differences and Similarities in TRAIL- and Tumor Necrosis Factor-Mediated Necroptotic Signaling in Cancer Cells.},
  author={Justyna Sosna and Stephan Ernst Philipp and Johaiber Fuchslocher Chico and Carina Saggau and J{\"u}rgen Fritsch and Alexandra F{\"o}ll and Johannes Plenge and Christoph Arenz and Thomas Pinkert and Holger Kalthoff and Anna Trauzold and Ingo Schmitz and Stephan Sch{\"u}tze and Dieter Adam},
  journal={Molecular and cellular biology},
  year={2016},
  volume={36 20},
  pages={
          2626-44
        }
}
Recently, a type of regulated necrosis (RN) called necroptosis was identified to be involved in many pathophysiological processes and emerged as an alternative method to eliminate cancer cells. However, only a few studies have elucidated components of TRAIL-mediated necroptosis useful for anticancer therapy. Therefore, we have compared this type of cell death to tumor necrosis factor (TNF)-mediated necroptosis and found similar signaling through acid and neutral sphingomyelinases, the… CONTINUE READING

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