Differences among HIV-1 variants in their ability to elicit secretion of TNF-alpha.

@article{Khanna2000DifferencesAH,
  title={Differences among HIV-1 variants in their ability to elicit secretion of TNF-alpha.},
  author={Kristen V. Khanna and Xiao Fei Yu and David Ford and L. S. Ratner and James E. K. Hildreth and Richard B. Markham},
  journal={Journal of immunology},
  year={2000},
  volume={164 3},
  pages={1408-15}
}
HIV-1 infection of human PBMC has been shown to elicit secretion of several different cytokines. TNF-alpha secretion induced by this virus has been of particular interest because it has been associated with the development of HIV-1 dementia and because TNF-alpha increases viral replication by enhancing NF-kappaB interaction with the viral promoter, the HIV-1 long terminal repeat. Thus, an autocrine pathway is potentially created in which HIV-1 stimulates its own replication. Conflicting reports… CONTINUE READING