Difference in tolerance development of hypothermia and pentobarbital-induced sleep prolongating effect of 11-hydroxy-delta 8-tetrahydrocannabinol and 11-oxo-delta 8-tetrahydrocannabinol in mice.

Daily administration (5 mg/kg i.v.) of 11-hydroxy-delta 8-tetrahydrocannabinol or 11-oxo-delta 8-tetrahydrocannabinol as well as delta 8-tetrahydrocannabinol quickly induced tolerance to their hypothermic effects in mice. Tolerance also developed to their pentobarbital-induced sleep prolongating effects. However, the degrees of tolerance development… CONTINUE READING