Difference in the way of macrophage recognition of target cells depending on their apoptotic states

@article{Fujii2001DifferenceIT,
  title={Difference in the way of macrophage recognition of target cells depending on their apoptotic states},
  author={Chifumi Fujii and Akiko Shiratsuchi and Junko Manaka and Shin Yonehara and Yoshinobu Nakanishi},
  journal={Cell Death and Differentiation},
  year={2001},
  volume={8},
  pages={1113-1122}
}
Dying cells are selectively eliminated from the organism by phagocytosis. Previous studies suggested the existence of some other phagocytosis marker(s) that function together with phosphatidylserine, the best-characterized phagocytosis marker. We obtained here a monoclonal antibody named PH2 that inhibited macrophage phagocytosis of late apoptotic or necrotic cells, but not of early apoptotic cells. On the other hand, phagocytosis of cells at any time during the process of apoptosis was… CONTINUE READING