Difference in the cardioprotective mechanisms between ischemic preconditioning and pharmacological preconditioning by diazoxide in rat hearts.

@article{Wakahara2004DifferenceIT,
  title={Difference in the cardioprotective mechanisms between ischemic preconditioning and pharmacological preconditioning by diazoxide in rat hearts.},
  author={Nobuyuki Wakahara and Hideki Katoh and Yasuhiro Yaguchi and Akihiko Uehara and Hiroshi Satoh and Hajime Terada and Yutaka Fujise and Hideharu Hayashi},
  journal={Circulation journal : official journal of the Japanese Circulation Society},
  year={2004},
  volume={68 2},
  pages={
          156-62
        }
}
BACKGROUND Recent studies have implicated the opening of mitochondrial K(ATP) (mitoK(ATP)) channels and the production of reactive oxygen species (ROS) in the cardioprotective mechanism of ischemic preconditioning (IPC). METHODS AND RESULTS The involvement of mitoK(ATP) channels and ROS in the cardioprotective effects of both IPC and the mitoK(ATP) channel opener diazoxide (DZ) was investigated in ischemic/reperfused rat hearts. The effects of IPC and DZ on myocardial high-energy phosphate… CONTINUE READING