Difference in developmental toxicity among structurally similar N-phenylimide herbicides in rats and rabbits.

@article{Kawamura2013DifferenceID,
  title={Difference in developmental toxicity among structurally similar N-phenylimide herbicides in rats and rabbits.},
  author={Satoshi Kawamura and Terushige Kato and Noboru Kannan and Alan G. Fantel},
  journal={Birth defects research. Part B, Developmental and reproductive toxicology},
  year={2013},
  volume={98 6},
  pages={
          437-44
        }
}
BACKGROUND S-53482 is an N-phenylimide herbicide and shows a remarkable species difference in developmental toxicity between rats and rabbits. The herbicide produced embryolethality, teratogenicity (mainly ventricular septal defects and wavy ribs), and growth retardation in rats, but not in rabbits. Our objective in this study was to investigate differences in developmental toxicity among N-phenylimide compounds structurally similar to S-53482 to better characterize the developmental effects of… Expand
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