Difference between type I autoimmune inhibitors of fibrin stabilization in two patients with severe hemorrhagic disorder.


Inhibitors of fibrin stabilization of apparently autoimmune origin, found in two severely bleeding unrelated patients (W. G. and G. A.), were compared with regard to their biological target specificities, potencies and immunological characteristics. Both interfered only with the activation of fibrin stabilizing factor (coagulation Factor XIII) and, while… (More)


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