Difference between single and multiple dose pharmacokinetics of orphenadrine hydrochloride in man

  title={Difference between single and multiple dose pharmacokinetics of orphenadrine hydrochloride in man},
  author={Johannes Jacobus Maria Labout and Charlotte Thijssen and G. G. J. Keijser and W. Hespe},
  journal={European Journal of Clinical Pharmacology},
SummaryPlasma concentrations of orphenadrine were measured by a specific gaschromatographic method in 5 healthy male volunteers after a single oral dose of orphenadrine hydrochloride 100mg. The single dose pharmacokinetic profile of orphenadrine was evaluated from these data. The elimination half-life ranged from 13.2–20.1 h after the commercial tablet formulation. Plasma concentrations, determined in volunteers and patients under different conditions of repeated oral administration of the same… 

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