Difference between kwashiorkor and marasmus: Comparative meta-analysis of pathogenic characteristics and implications for treatment.

@article{Pham2020DifferenceBK,
  title={Difference between kwashiorkor and marasmus: Comparative meta-analysis of pathogenic characteristics and implications for treatment.},
  author={Thi-Phuong-Thao Pham and Maryam Tidjani Alou and Michael H. Golden and Matthieu Million and Didier Raoult},
  journal={Microbial pathogenesis},
  year={2020},
  pages={
          104702
        }
}

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References

SHOWING 1-10 OF 102 REFERENCES

Gut Microbiota Alteration is Characterized by a Proteobacteria and Fusobacteria Bloom in Kwashiorkor and a Bacteroidetes Paucity in Marasmus

TLDR
A biological basis is provided to support the usage of an antibiotic therapy more effective in suppressing the overgrowth of bacterial communities resistant to penicillin, combined with antioxidants and probiotics for nutritional recovery therapies, particularly for kwashiorkor.

Reduced production of sulfated glycosaminoglycans occurs in Zambian children with kwashiorkor but not marasmus.

TLDR
It is speculated that a genetic predisposition to reduced HSPG biosynthesis may offer a contrasting selective advantage, by both diminishing protein catabolism during transient undernutrition and protecting against specific infectious diseases.

Prenatal Factors Contribute to the Emergence of Kwashiorkor or Marasmus in Severe Undernutrition: Evidence for the Predictive Adaptation Model

TLDR
Data from the Tropical Metabolism Research Unit Ward of the University Hospital of the West Indies, Kingston, Jamaica during 1962–1992 are consistent with a model suggesting that plastic mechanisms operative in utero induce potential marasmics to develop with a metabolic physiology more able to adapt to postnatal undernutrition than those of higher birthweight.

Gut Bacteria Missing in Severe Acute Malnutrition, Can We Identify Potential Probiotics by Culturomics?

TLDR
Stool samples of malnourished patients with kwashiorkor and healthy children were collected from Niger and Senegal and analyzed, finding a globally decreased diversity, a decrease in the hitherto unknown diversity (new species isolation), a depletion in oxygen-sensitive prokaryotes and an enrichment in potentially pathogenic Proteobacteria, Fusobacteria and Streptococcus gallolyticus.

Increased Gut Redox and Depletion of Anaerobic and Methanogenic Prokaryotes in Severe Acute Malnutrition

TLDR
A unifying theory linking microbiota specificity, lacking anaerobes and archaea, to low antioxidant nutrients, and lower food conversion is proposed.

Kwashiorkor in the United States: fad diets, perceived and true milk allergy, and nutritional ignorance.

TLDR
Physicians should consider the diagnosis of kwashiorkor in children with perceived milk allergies resulting in frequent dietary manipulations, in children following fad or unorthodox diets, or in children living in homes with significant social chaos.

Whole-body protein kinetics in marasmus and kwashiorkor during acute infection.

TLDR
The hypothesis that rates of whole-body protein synthesis and breakdown are higher in marasmus than in kwashiorkor during acute infection is tested and HIV infection and body composition did not explain the differences.

Lipid transport in kwashiorkor

TLDR
The findings support the suggestion that the primary mechanism in the production of the fatty liver of kwashiorkor is an impairment in the synthesis of lipoprotein of very low density, probably due to the rate-limiting synthesis of its protein moiety.

Free Radicals in the Pathogenesis of Kwashiorkor

TLDR
It is proposed that kwashiorkor results from an imbalance between the production of free radicals and their safe disposal (Golden, 1985), and the evidence for such a hypothesis is examined.

Metabolomic Changes in Serum of Children with Different Clinical Diagnoses of Malnutrition123

TLDR
Children with kwashiorkor were metabolically distinct from those with marasmus, and were more prone to severe metabolic disruptions, which may explain the poor long-term outcomes in these children.
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