Difference between kwashiorkor and marasmus: Comparative meta-analysis of pathogenic characteristics and implications for treatment.

  title={Difference between kwashiorkor and marasmus: Comparative meta-analysis of pathogenic characteristics and implications for treatment.},
  author={Thi-Phuong-Thao Pham and Maryam Tidjani Alou and Michael H. Golden and Matthieu Million and Didier Raoult},
  journal={Microbial pathogenesis},

Influence of Malnutrition on the Pharmacokinetics of Drugs Used in the Treatment of Poverty-Related Diseases: A Systematic Review

Effectes were heterogeneous, but trends were observed for specific classes of drugs and different types and degrees of malnutrition, and Clinically relevant effects were mainly observed in severely malnourished and kwashiorkor patients.

A Listeria monocytogenes clone in human breast milk associated with severe acute malnutrition in West Africa: A multicentric case-controlled study

A previously unsuspected carriage of L. monocytogenes in the breast milk of West African women, which is associated with severe acute malnutrition, is revealed and might provide new therapeutic and inexpensive options to prevent and treat this neglected public health issue.

Validation of a Feed Protocol in a Mouse Model That Mimics Marasmic Malnutrition

A feeding protocol was able to generate mild malnutrition and cause changes in the nutritional status of mice that could be similar to those observed in marasmic malnutrition.


The scientific development and subsequent “Vitamin D and antibodies” continues to influence the researchers all over the globe today and this article examines the research done and published by researchers and scientists.

Virgibacillus doumboii sp. nov., a halophilic bacterium isolated from the stool of a healthy child in Mali



Gut Microbiota Alteration is Characterized by a Proteobacteria and Fusobacteria Bloom in Kwashiorkor and a Bacteroidetes Paucity in Marasmus

A biological basis is provided to support the usage of an antibiotic therapy more effective in suppressing the overgrowth of bacterial communities resistant to penicillin, combined with antioxidants and probiotics for nutritional recovery therapies, particularly for kwashiorkor.

Reduced production of sulfated glycosaminoglycans occurs in Zambian children with kwashiorkor but not marasmus.

It is speculated that a genetic predisposition to reduced HSPG biosynthesis may offer a contrasting selective advantage, by both diminishing protein catabolism during transient undernutrition and protecting against specific infectious diseases.

Prenatal Factors Contribute to the Emergence of Kwashiorkor or Marasmus in Severe Undernutrition: Evidence for the Predictive Adaptation Model

Data from the Tropical Metabolism Research Unit Ward of the University Hospital of the West Indies, Kingston, Jamaica during 1962–1992 are consistent with a model suggesting that plastic mechanisms operative in utero induce potential marasmics to develop with a metabolic physiology more able to adapt to postnatal undernutrition than those of higher birthweight.

Gut Bacteria Missing in Severe Acute Malnutrition, Can We Identify Potential Probiotics by Culturomics?

Stool samples of malnourished patients with kwashiorkor and healthy children were collected from Niger and Senegal and analyzed, finding a globally decreased diversity, a decrease in the hitherto unknown diversity (new species isolation), a depletion in oxygen-sensitive prokaryotes and an enrichment in potentially pathogenic Proteobacteria, Fusobacteria and Streptococcus gallolyticus.

Increased Gut Redox and Depletion of Anaerobic and Methanogenic Prokaryotes in Severe Acute Malnutrition

A unifying theory linking microbiota specificity, lacking anaerobes and archaea, to low antioxidant nutrients, and lower food conversion is proposed.

Kwashiorkor in the United States: fad diets, perceived and true milk allergy, and nutritional ignorance.

Physicians should consider the diagnosis of kwashiorkor in children with perceived milk allergies resulting in frequent dietary manipulations, in children following fad or unorthodox diets, or in children living in homes with significant social chaos.

Whole-body protein kinetics in marasmus and kwashiorkor during acute infection.

The hypothesis that rates of whole-body protein synthesis and breakdown are higher in marasmus than in kwashiorkor during acute infection is tested and HIV infection and body composition did not explain the differences.

Lipid transport in kwashiorkor

The findings support the suggestion that the primary mechanism in the production of the fatty liver of kwashiorkor is an impairment in the synthesis of lipoprotein of very low density, probably due to the rate-limiting synthesis of its protein moiety.

Free Radicals in the Pathogenesis of Kwashiorkor

It is proposed that kwashiorkor results from an imbalance between the production of free radicals and their safe disposal (Golden, 1985), and the evidence for such a hypothesis is examined.

Metabolomic Changes in Serum of Children with Different Clinical Diagnoses of Malnutrition123

Children with kwashiorkor were metabolically distinct from those with marasmus, and were more prone to severe metabolic disruptions, which may explain the poor long-term outcomes in these children.