Diff-seq: A high throughput sequencing-based mismatch detection assay for DNA variant enrichment and discovery.

Abstract

Much of the within species genetic variation is in the form of single nucleotide polymorphisms (SNPs), typically detected by whole genome sequencing (WGS) or microarray-based technologies. However, WGS produces mostly uninformative reads that perfectly match the reference, while microarrays require genome-specific reagents. We have developed Diff-seq, a… (More)
DOI: 10.1093/nar/gky022

Topics

4 Figures and Tables

Slides referencing similar topics