Diferuloylmethane augments the cytotoxic effects of piplartine isolated from Piper chaba.

@article{Jyothi2009DiferuloylmethaneAT,
  title={Diferuloylmethane augments the cytotoxic effects of piplartine isolated from Piper chaba.},
  author={D. Shanmukhi Jyothi and P. Vanathi and P Mangala Gowri and V. Rama Subba Rao and J. Madhusudana Rao and Amere Subbarao Sreedhar},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  year={2009},
  volume={23 6},
  pages={
          1085-91
        }
}
  • D. Jyothi, P. Vanathi, A. S. Sreedhar
  • Published 1 September 2009
  • Biology, Chemistry
  • Toxicology in vitro : an international journal published in association with BIBRA
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References

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Piplartine induces inhibition of leukemia cell proliferation triggering both apoptosis and necrosis pathways.
Antiproliferative Effects of Two Amides, Piperine and Piplartine, from Piper Species
TLDR
None of the tested substances induced hemolysis of mouse erythrocytes, suggesting that the cytotoxicity of piplartine and piperine was not related to membrane damage.
Anticancer potential of curcumin: preclinical and clinical studies.
TLDR
Evidence has also been presented to suggest that curcumin can suppress tumor initiation, promotion and metastasis, and Pharmacologically,Curcumin has been found to be safe.
In vitro and in vivo antitumor effect of 5‐FU combined with piplartine and piperine
TLDR
Piplartine may enhance the therapeutic effectiveness of chemotherapeutic drugs, and moreover, this combination could improve immunocompetence hampered by 5‐FU, according to the findings.
In vivo growth-inhibition of Sarcoma 180 by piplartine and piperine, two alkaloid amides from Piper.
  • D. Bezerra, F. Castro, L. Costa-Lotufo
  • Biology, Chemistry
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
  • 2006
TLDR
Histopathological and morphological analyses of the tumor and the organs, including liver, spleen, and kidney, were performed in order to evaluate the toxicological aspects of the treatment with these amides and it was shown that both organs were reversibly affected by piplartine and piperine treatment, but in a different way.
New cytotoxic cyclobutanoid amides, a new furanoid lignan and anti-platelet aggregation constituents from Piper arborescens.
TLDR
Piplartine showed the most potent anti-platelet aggregation activity induced by collagen and showed an IC50 value of 21.5 microM, while Piperarborenines A - E, piperarborenine, aristololactam BIII and goniothalactam showed significant cytotoxic activity against P-388, HT-29 and A549 cell lines in vitro.
Multi-targeted therapy by curcumin: how spicy is it?
TLDR
Curcumin regulates multiple targets (multitargeted therapy), which is needed for treatment of most diseases, and it is inexpensive and has been found to be safe in human clinical trials.
Biochemical basis of enhanced drug bioavailability by piperine: evidence that piperine is a potent inhibitor of drug metabolism.
TLDR
It is demonstrated that piperine is a nonspecific inhibitor of drug metabolism which shows little discrimination between different cytochrome P-450 forms.
Hyperthermia and Pharmacological Intervention of Heat Shock Proteins in Anticancer Treatments
TLDR
Selective combination of anti-Hsp drugs with hyperthermia have been shown to have the desired cytostatic/cytotoxic effects in some tumor models and a discussion of the effects of enforced apoptosis using anti- Hsp inhibitors, and facilitated apoptosis with hyperThermia, either alone or in combination is presented.
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