Diferric transferrin reductase in the plasma membrane is inhibited by adriamycin.

@article{Sun1987DiferricTR,
  title={Diferric transferrin reductase in the plasma membrane is inhibited by adriamycin.},
  author={Iris Sun and Pl{\'a}cido Navas and Frederick L. Crane and Dorothy M. Morr{\'e} and Hans Loew},
  journal={Biochemistry international},
  year={1987},
  volume={14 1},
  pages={119-27}
}
Diferric transferrin which is often necessary for growth of cells is reduced by the transplasma membrane electron transport system of HeLa cells with release of ferrous iron outside the cell. Reduction of external diferric transferrin is reflected in oxidation of internal NADH. Adriamycin, an antitumor drug, inhibits diferric transferrin reduction by the HeLa cells and inhibits concomittant oxidation of cytosolic NADH at concentrations, 10(-8)-10(-6)M, which inhibit cell growth. Isolated liver… CONTINUE READING