• Corpus ID: 1255667

Diets containing whey proteins or soy protein isolate protect against 7,12-dimethylbenz(a)anthracene-induced mammary tumors in female rats.

@article{Hakkak2000DietsCW,
  title={Diets containing whey proteins or soy protein isolate protect against 7,12-dimethylbenz(a)anthracene-induced mammary tumors in female rats.},
  author={Reza Hakkak and Sohelia Korourian and Susan R Shelnutt and Shelly V Lensing and Martin J J Ronis and Thomas M. Badger},
  journal={Cancer epidemiology, biomarkers \& prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  year={2000},
  volume={9 1},
  pages={
          113-7
        }
}
  • R. Hakkak, S. Korourian, T. Badger
  • Published 2000
  • Biology, Medicine
  • Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
A study was conducted to determine the protective effects of two common dietary proteins, soy protein isolate (soy) and bovine whey, against chemically induced mammary tumors in female Sprague Dawley rats. Rats were fed AIN-93G diets having casein, soy, or whey as the sole protein source. Rats within the same dietary groups were mated to obtain the F1 and F2 generations. At age 50 days, F1 (experiment A) or F2 (experiment B) female offspring (> or =19 rats/group) were p.o. gavaged with 80 mg/kg… 

Figures and Tables from this paper

Whey Protein Hydrolysate but not Whole Whey Protein Protects Against 7,12-Dimethylbenz(a)anthracene-Induced Mammary Tumors in Rats
TLDR
Results demonstrate that hydrolytic processing of whey protein is required for this diet to be effective in reducing DMBA-induced mammary tumors and the bioactive compounds produced during wheyprotein processing and mechanisms underlying the anticancer effects of WPH are yet to be identified.
Dietary whey protein protects against azoxymethane-induced colon tumors in male rats.
TLDR
Consumption of whey protein-containing diets may reduce the risk of developing colon tumors, and the effects of casein and whey diets on chemically induced colon cancer in male rats are investigated.
Effects of high-isoflavone soy diet vs. casein protein diet and obesity on DMBA-induced mammary tumor development.
TLDR
The results suggest that female Zucker rats fed casein diets are protected against DMBA-induced mammary tumors, which is not the case for those on high-isoflavone soy diet, and changes in the concentration of serum IGFBP-3 may contribute to the incidence ofDMBA- induced mammary tumor development.
Beneficial effects of soy protein in the initiation and progression against dimethylbenz [a] anthracene-induced breast tumors in female rats
TLDR
The findings suggest that the soy protein may protect against the development of a more aggressive breast carcinoma.
Nutrition and Cancer Soy and Whey Proteins Downregulate DMBA-Induced Liver and Mammary Gland CYP 1 Expression in Female Rats 1
TLDR
The results demonstrate the importance of diet in regulation of phase I metabolism in liver and mammary gland, and suggest a potential mechanism by which soy or whey proteins reduce DMBA-induced mammary tumor incidence.
Diet Supplementation with Soy Protein Isolate, but Not the Isoflavone Genistein, Protects Against Alcohol-Induced Tumor Progression in DEN-Treated Male Mice.
TLDR
It is suggested that soy prevents tumorigenesis by reducing inflammation and by reducing hepatocyte proliferation through inhibition of EtOH-mediated β-catenin signaling.
Altered mammary gland differentiation and progesterone receptor expression in rats fed soy and whey proteins.
TLDR
Results show that the type of dietary protein alters the phenotype of mammary epithelia in the TEBs, and the SPI- and WPH-dependent changes in mammary differentiation may contribute to the reduced sensitivity to DMBA-induced mammary cancer in rats fed these proteins.
Dietary exposure to whey proteins alters rat mammary gland proliferation, apoptosis, and gene expression during postnatal development.
TLDR
Results demonstrate that dietary WPH advances mammary gland differentiation during neonatal development and suggest that the transiently increased expression of the pro-apoptotic signal PTEN during a sensitive developmental window may partly underlie the cancer protective effects of WPH.
Soy and whey proteins downregulate DMBA-induced liver and mammary gland CYP1 expression in female rats.
TLDR
The results demonstrate the importance of diet in regulation of phase I metabolism in liver and mammary gland, and suggest a potential mechanism by which soy or whey proteins reduce DMBA-induced mammary tumor incidence.
...
...

References

SHOWING 1-10 OF 28 REFERENCES
Dietary soybean isolate and methionine supplementation affect mammary tumor progression in rats.
TLDR
Data indicate that SBP diet, low in methionine content, fed 5 wk after carcinogen exposure significantly repressed mammary tumor progression, and Methionine supplementation increased the number of animals with tumors but not the mean tumor weight.
Soy and experimental cancer: animal studies.
TLDR
Data suggest an inhibitory effect on mammary epithelial growth in the soy-protein-fed group, which was demonstrated after carcinogen administration (at 7 weeks of age), ornithine decarboxylase activity and polyamine concentrations in the rat Mammary epithelium were significantly lower in the Soy protein group.
The influence of dietary whey protein on tissue glutathione and the diseases of aging.
TLDR
A whey protein diet appears to enhance the liver and heart glutathione concentration in aging mice and to increase longevity over a 6.3 month observation period.
AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet.
TLDR
Two new diets may prove to be a better choice than AIN-76A for long-term as well as short-term studies with laboratory rodents because of a better balance of essential nutrients.
Phytoestrogens in Soy-Based Infant Foods: Concentrations, Daily Intake, and Possible Biological Effects
TLDR
It is suggested that it would be highly desirable to study the effects of soy isoflavones on steroid-dependent developmental processes in human babies, since neonates are generally more susceptible than adults to perturbations of the sex steroid milieu.
Whey proteins in cancer prevention.
Neonatal Genistein Chemoprevents Mammary Cancer
TLDR
A precocious maturation of undifferentiated terminal end buds to more differentiated lobules may account for neonatal genistein treatment protecting against chemically induced mammary cancer.
Experimental evidence of dietary factors and hormone-dependent cancers.
TLDR
Both caloric restriction and dietary fat appear to act primarily during the preneoplastic state, and their effects on hormone-dependent tumors may be mediated through changes in the hormonal environment.
90-day feeding and one-generation reproduction study in Crl:CD BR rats with 17 beta-estradiol.
TLDR
This 90-day/one-generation reproduction study with 17 beta-estradiol was designed to set dose levels for future multigenerational reproduction and combined chronic toxicity/oncogenicity studies, and to provide benchmark data for a risk assessment for chemicals with estrogen-like activities.
Dietary effects on breast-cancer risk in Singapore
...
...