Diets containing soy protein isolate increase hepatic CYP3A expression and inducibility in weanling male rats exposed during early development.

@article{Ronis2004DietsCS,
  title={Diets containing soy protein isolate increase hepatic CYP3A expression and inducibility in weanling male rats exposed during early development.},
  author={Martin J. J. Ronis and Yin Chen and Chan-He Jo and Pippa Simpson and T M Badger},
  journal={The Journal of nutrition},
  year={2004},
  volume={134 12},
  pages={3270-6}
}
Hepatic CYP3A enzymes were studied in weanling male Sprague-Dawley rats exposed to diets from gestational d 4 in which the sole protein source was either casein (CAS) or soy protein isolate (SPI). At age 25 d, rats were gavaged with corn oil or one of the CYP3A inducers, dexamethasone (DEX) and clotrimazole (CLT), at a dose of 50 mg/kg. Little CYP3A1 (CYP3A23), CYP3A2, or CYP3A9 mRNA was observed in CAS-fed weanling rats but CYP3A18 mRNA was readily detectable in Northern blots. In contrast… CONTINUE READING