Diethylstilbestrol revisited: a review of the long-term health effects.

  title={Diethylstilbestrol revisited: a review of the long-term health effects.},
  author={Ruthann M Giusti and Kunihiko Iwamoto and Elizabeth E Hatch},
  journal={Annals of internal medicine},
  volume={122 10},
Although the use of diethylstilbestrol (DES) during pregnancy was banned in 1971, unanswered questions on known and suspected health outcomes and the potential for third-generation effects have persisted. Attempts to address these concerns have been frustrated by the inability to retrospectively confirm DES exposure, by the relative rarity of purported health outcomes, by a lack of understanding of the mechanism or mechanisms through which DES causes adverse effects, and by the perception that… CONTINUE READING


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