Diethylstilbestrol impaired oogenesis of yellow catfish juveniles through disrupting hypothalamic-pituitary-gonadal axis and germ cell development.

@article{Wang2018DiethylstilbestrolIO,
  title={Diethylstilbestrol impaired oogenesis of yellow catfish juveniles through disrupting hypothalamic-pituitary-gonadal axis and germ cell development.},
  author={Yaqin Wang and Yingwen Li and Qiliang Chen and Zhihao Liu},
  journal={Journal of applied toxicology : JAT},
  year={2018},
  volume={38 3},
  pages={
          308-317
        }
}
Diethylstilbestrol (DES), a non-steroidal estrogen, has been found to cause altered germ cell development and disordered ovarian development in fish females. However, the mechanisms that might be involved are poorly understood. In this study, female juveniles of yellow catfish (Pelteobagrus fulvidraco) (120 days post-hatching) were exposed to two doses (10 and 100 ng l-1 ) of DES for 28 days. After the endpoint of exposure, decreased ovary weight and gonadosomatic index, as well as various… CONTINUE READING
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