Diethylene glycol poisoning

@article{Schep2009DiethyleneGP,
  title={Diethylene glycol poisoning},
  author={L. Schep and R. Slaughter and W. Temple and D. M. Beasley},
  journal={Clinical Toxicology},
  year={2009},
  volume={47},
  pages={525 - 535}
}
Introduction. Diethylene glycol (DEG) is a clear, colorless, practically odorless, viscous, hygroscopic liquid with a sweetish taste. In addition to its use in a wide range of industrial products, it has also been involved in a number of prominent mass poisonings spanning back to 1937. Despite DEG's toxicity and associated epidemics of fatal poisonings, a comprehensive review has not been published. Methods. A summary of the literature on DEG was compiled by systematically searching OVID… Expand
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The results indicate that the mechanism for the target organ toxicity results from metabolites of DEG, and not DEG itself nor formation of EG from DEg, and that fomepizole may be a useful antidote for treating DEG poisoning. Expand
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References

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Diethylene glycol: widely used solvent presents serious poisoning potential.
TLDR
A case of intentional ingestion of a wallpaper stripper containing DEG resulting in severe multi-system organ failure and severe neurologic sequelae is described, demonstrating the severe toxicity of DEG. Expand
Identification and quantification of diethylene glycol in pharmaceuticals implicated in poisoning epidemics: an historical laboratory perspective.
TLDR
The historical approach to identifying and quantifying DEG during each of these outbreaks is described, which includes the development of biomarkers of DEG exposure, which would be extremely useful in instances where pharmaceuticals are not clearly implicated. Expand
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TLDR
It has been suggested by the American investigators of this disaster that suiphanilamide and diethylene glycol may produce additive toxic actions when given in combination. Expand
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According to reports, at least seventy-six human beings in various localities died as a result of poisoning by Elixir of Sulfanilamide-Massengill during the months of September and October 1937. Expand
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TLDR
In acute DEG poisoning, both the mechanism and the treatment appear to be the same as in acute EG intoxication, and the ability of ethanol infusions to prevent hepatic oxidation of DEG has not been proved. Expand
Delayed Neurologic Sequelae Resulting from Epidemic Diethylene Glycol Poisoning
TLDR
A series of seven patients presenting with epidemic DEG poisoning from a correctional facility with varying degrees of metabolic acidemia and acute renal impairment responding to emergent hemodialysis (HD) develop delayed neurologic toxicity which has not been well characterized in the past. Expand
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TLDR
Fomepizole has clear advantages over ethanol in terms of validated efficacy, predictable pharmacokinetics, ease of administration, and lack of adverse effects, whereas ethanol hasclear advantages over fome pizole in Terms of long-term clinical experience and acquisition cost. Expand
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TLDR
The pancreatic, central and peripheral nervous system lesions as well as the glomerular arteriolar hyalinosis have not been previously described in the literature in relation with diethylene glycol poisoning. Expand
Intravenous 4-methylpyrazole as an antidote for diethylene glycol and triethylene glycol poisoning: a case report.
TLDR
A young female suicidally ingested DEG and TEG was presented in metabolic acidosis with coma, given 4-methylpyrazole (4-MP), an ADH inhibitor, the acidosis resolved, the patient recovered and was discharged without sequelae. Expand
It's happening again--another diethylene glycol mass poisoning.
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TLDR
This sort of poisoning is bound to occur again unless much stricter pharmaceutical manufacturing oversight is employed and enforced throughout the world and developing countries with fewer resources to implement quality control monitoring will continue to be at higher risk for such poisoning epidemics. Expand
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