Diethylene glycol monobutyl ether (DGBE): two- and thirteen-week oral toxicity studies in Fischer 344 rats.

@article{Johnson2005DiethyleneGM,
  title={Diethylene glycol monobutyl ether (DGBE): two- and thirteen-week oral toxicity studies in Fischer 344 rats.},
  author={Keith A. Johnson and Phyllip Baker and H Lynn Kan and Jacques P J Maurissen and Pamela J. Spencer and Mary Sue Marty},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={2005},
  volume={43 3},
  pages={467-81}
}
Standard toxicologic endpoints, supplemented by additional examinations, were studied for groups of 10 Fischer 344 rats/sex given drinking water formulated to supply 0, 50, 250, or 1000 mg diethylene glycol monobutyl ether (DGBE)/kg/day for 13 weeks. These dose levels were based upon initial investigations using drinking water formulated to supply 0, 1000, 1500 or 2000 mg DGBE/kg/day for two weeks. All rats survived the respective treatment intervals with no adverse treatment-related in-life… CONTINUE READING