Diethyldithiocarbamate suppresses the plant activation of aromatic amines into mutagens by inhibiting tobacco cell peroxidase.

@article{Plewa1991DiethyldithiocarbamateST,
  title={Diethyldithiocarbamate suppresses the plant activation of aromatic amines into mutagens by inhibiting tobacco cell peroxidase.},
  author={Michael J. Plewa and S. Ray Smith and Elizabeth D. Wagner},
  journal={Mutation research},
  year={1991},
  volume={247 1},
  pages={
          57-64
        }
}
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159 Citations

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Characterization of 4-nitro-o-phenylenediamine activation by plant systems.
Plant activation of aromatic amines mediated by cytochromes P450 and flavin-containing monooxygenases.
Activation of arylamines to mutagenic product(s) by two in vitro plant systems.
Induction of somatic mutations in Tradescantia clone 4430 by three phenylenediamine isomers and the antimutagenic mechanisms of diethyldithiocarbamate and ammonium meta-vanadate.
Metabolic activation of three arylamines and two organophosphorus insecticides by coriander (Coriandrum sativum) a common edible vegetable.
o-Phenylenediamine-induced DNA damage and mutagenicity in tobacco seedlings is light-dependent.
Activation of 4-nitro-o-phenylenediamine by the S2 fraction of Zea mays to mutagenic product(s).
The role of plant metabolism in the mutagenic and cytotoxic effects of four organophosphorus insecticides in Salmonella typhimurium and in human cell lines.
The metabolic activation of 4-nitro-o-phenylenediamine by chlorophyll-containing plant extracts: the relationship between mutagenicity and antimutagenicity.
Plant activation and its role in environmental mutagenesis and antimutagenesis.
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References

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TLDR
The data implicate a TX1 cell peroxidase and a FAD‐dependent monooxygenase in the plant activation of m‐phenylenediamine and an additional pathway of the plant cells in the activation of 2‐aminofluorene may involve a cytochrome P‐448‐type N‐hydroxylase.
The plant cell/microbe coincubation assay for the analysis of plant-activated promutagens.
Plant activation of m‐phenylenediamine by tobacco, cotton, and carrot cell suspension cultures
TLDR
It is concluded that m‐phenylenediamine is activated by plant cells into a mutagen that primarily induces frameshift mutations.
Evidence for a one-electron mechanism of 2-aminofluorene oxidation by prostaglandin H synthase and horseradish peroxidase.
Phenazine derivatives as the mutagenic reaction product from o- or m-phenylenediamine derivatives with hydrogen peroxide.
Carcinogenicity of an oxidation product of p-phenylenediamine.
TLDR
In female rats, both topical application and s.c. injection for 18 months of oxidized p-PD could induce a statistically significant incidence of mammary gland tumors, and tumors of other organs including liver, kidney, adrenal gland, thyroid gland, urinary bladder and lung were occasionally observed in male rats of both groups and might be related to the p- PD treatment.
Antioxidant capacity of diethyldithiocarbamate in a metal independent lipid peroxidative process.
Relation between hepatic microsomal metabolism of N-nitrosamines and cytochrome P-450 species.
The oxidation of 2-aminofluorene by prostaglandin endoperoxide synthetase. Comparison with other peroxidases.
TLDR
Results suggest that 2-AF is oxidized to an electrophilic intermediate(s) by prostaglandin endoperoxide synthetase, which either binds covalently to tissue macromolecules or is further rapidly oxidizing to 2-nitrofluorene and azofluorene.
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