Diethyldithiocarbamate causes nigral cell loss and dopamine depletion with nontoxic doses of MPTP.

@article{Walters1999DiethyldithiocarbamateCN,
  title={Diethyldithiocarbamate causes nigral cell loss and dopamine depletion with nontoxic doses of MPTP.},
  author={T L Walters and Ian Irwin and Kioumars Delfani and James William Langston and Ann Marie Janson},
  journal={Experimental neurology},
  year={1999},
  volume={156 1},
  pages={62-70}
}
Although nontoxic when administered alone, diethyldithiocarbamate (DDC) is known to enhance the dopamine-depleting effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the mouse striatum. The purpose of the present study was twofold: (i) to carefully characterize the effects of DDC on MPTP-induced degeneration of dopaminergic neurons in substantia nigra pars compacta using unbiased, stereological cell counting techniques and (ii) to determine whether or not DDC can convert a… CONTINUE READING