Diethylcarbamazine Attenuates the Development of Carrageenan-Induced Lung Injury in Mice

  title={Diethylcarbamazine Attenuates the Development of Carrageenan-Induced Lung Injury in Mice},
  author={Edlene Lima Ribeiro and Karla Patr{\'i}cia Sousa Barbosa and Ingrid Tavares Fragoso and Mariana Arag{\~a}o Matos Donato and Fabiana Oliveira dos Santos Gomes and Bruna Santos da Silva and Amanda Karolina Soares Silva and Sura Wanessa Santos Rocha and Valdemiro Amaro da Silva Junior and Christina Alves Peixoto},
  journal={Mediators of Inflammation},
Diethylcarbamazine (DEC) is an antifilarial drug with potent anti-inflammatory properties as a result of its interference with the metabolism of arachidonic acid. The aim of the present study was to evaluate the anti-inflammatory activity of DEC in a mouse model of acute inflammation (carrageenan-induced pleurisy). The injection of carrageenan into the pleural cavity induced the accumulation of fluid containing a large number of polymorphonuclear cells (PMNs) as well as infiltration of PMNs in… 

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