Diethyl phthalate enhances expression of SIRT 1 , DNMT 3 a and DNMT 3 b during apoptosis in PC 12 Cells

@inproceedings{Sun2017DiethylPE,
  title={Diethyl phthalate enhances expression of SIRT 1 , DNMT 3 a and DNMT 3 b during apoptosis in PC 12 Cells},
  author={Yongkun Sun and Zhikun Guo and Shouhei Iku and Takeshi Saito and Masaaki Kurasaki},
  year={2017}
}
Diethyl phthalate works as a phthalate plasticizer and is ubiquitously used in personal care products, cosmetics, medical equipment and pha rmaceutical coating. Diethyl phthalate is considered a potential endocrine disruptor. P eviously we found diethyl phthalate enhanced apoptosis induced by serum deprivation in PC12 cells. However, the relationship between diethyl phthalate and longevity related fac tors, sirtuins, and epigenetic factors (e.g., DNA methyltransferases) remains unclear, because… CONTINUE READING