Diethyl hexyl phthalate-induced changes in insulin signaling molecules and the protective role of antioxidant vitamins in gastrocnemius muscle of adult male rat.

@article{Srinivasan2011DiethylHP,
  title={Diethyl hexyl phthalate-induced changes in insulin signaling molecules and the protective role of antioxidant vitamins in gastrocnemius muscle of adult male rat.},
  author={Chinnapaiyan Srinivasan and Adam Ismail Khan and Venkataraman Balaji and Jayaraman Selvaraj and Karundevi Balasubramanian},
  journal={Toxicology and applied pharmacology},
  year={2011},
  volume={257 2},
  pages={155-64}
}
Diethyl hexyl phthalate (DEHP) is an endocrine disruptor, it influences various organ systems in human beings and experimental animals. DEHP reduced the serum testosterone and increased the blood glucose, estradiol, T(3) and T(4) in rats. However, the effect of DEHP on insulin signaling and glucose oxidation in skeletal muscle is not known. Adult male albino rats were divided into four groups: Group I: Control; Groups II and III: DEHP treated (dissolved in olive oil at a dose of 10 and 100mg/kg… CONTINUE READING