Dietary zinc supplementation inhibits NFkappaB activation and protects against chemically induced diabetes in CD1 mice.

@article{Ho2001DietaryZS,
  title={Dietary zinc supplementation inhibits NFkappaB activation and protects against chemically induced diabetes in CD1 mice.},
  author={Emily E. Ho and Nancy N Quan and Yi Hung Tsai and Wenyan Lai and Tammy M. Bray},
  journal={Experimental biology and medicine},
  year={2001},
  volume={226 2},
  pages={
          103-11
        }
}
Zinc status in patients with Type I diabetes is significantly lower than healthy controls. Whether zinc supplementation can prevent the onset of Type I diabetes is unknown. Recent studies have suggested that the generation of reactive oxygen species (ROS) is a cause of beta cell death leading to Type I diabetes. In addition, we found that activation of NFkappaB (a ROS-sensitive transcription factor that regulates immune responses) may be the key cellular process that bridges oxidative stress… CONTINUE READING
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