Dietary vs. pharmacological doses of zinc: A clinical review.

@article{Santos2019DietaryVP,
  title={Dietary vs. pharmacological doses of zinc: A clinical review.},
  author={Heitor O. Santos and Filipe J. Teixeira and Brad Jon Schoenfeld},
  journal={Clinical nutrition},
  year={2019}
}
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References

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Use of medicinal doses of zinc as a safe and efficient coadjutant in the treatment of male hypogonadism
TLDR
The current body of evidence does not suggest broad recommendations regarding the use of zinc for all types of hypogonadism, and a common and safe recommendation is 220 mg of zinc sulfate twice a day, over one to four months.
Zinc toxicity.
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TLDR
Individuals using zinc supplements should be aware of the possible complications attendant to their use, and even lower levels of zinc supplementation have been suggested to interfere with the utilization of copper and iron and to adversely affect HDL cholesterol concentrations.
The Effect of Zinc Supplementation in Humans on Plasma Lipids, Antioxidant Status and Thrombogenesis
TLDR
Limited data suggest that sustained hyperzincaemia predisposes individuals to thrombogenesis, whereas acute zinc depletion impairs platelet aggregation and prolongs bleeding time, and there is insufficient evidence to determine the role of zinc supplementation in influencing other risk factors for CHD such as antioxidant status and thromBogenesis.
Effects of Zinc supplementation on serum lipids: a systematic review and meta-analysis
TLDR
Zinc supplementation significantly reduced total cholesterol, LDL cholesterol and triglycerides and may have the potential to reduce the incidence of atherosclerosis related morbidity and mortality.
Zinc supplementation decreases incidence of infections in the elderly: effect of zinc on generation of cytokines and oxidative stress.
TLDR
After zinc supplementation, the incidence of infections was significantlyLower, plasma zinc was significantly higher, and generation of tumor necrosis factor alpha and oxidative stress markers was significantly lower in the zinc-supplemented than in the placebo group.
Studies on the bioavailability of zinc in humans: intestinal interaction of tin and zinc.
TLDR
The tin/zinc interaction is explored using the change-in-plasma-zinc-concentration method with a standard dosage of 12.5 mg of zinc as zinc sulfate in 100 ml of Coca-Cola and a reduction of zinc absorption not dissimilar from that seen previously with zinc and iron alone.
Effect of Zinc Supplementation on Maintenance Hemodialysis Patients: A Systematic Review and Meta-Analysis of 15 Randomized Controlled Trials
TLDR
The analysis shows that zinc supplementation may benefit the nutritional status of MHD patients and show a time-effect relationship.
Effects of Zinc Supplementation on Plasma Copper/Zinc Ratios, Oxidative Stress, and Immunological Status in Hemodialysis Patients
TLDR
Zn supplementation ameliorates abnormally high plasma Cu/Zn ratios and may reduce oxidative stress, improve inflammatory status, and maintain immune function in patients undergoing long-term HD.
Dietary factors influencing zinc absorption.
TLDR
Knowledge about dietary factors that inhibit zinc absorption and about ways to overcome or remove these factors is essential when designing strategies to improve the zinc nutrition of vulnerable groups.
Zinc in Cancer Prevention
TLDR
In patients with head and neck cancer, it is shown that nearly 65% of these patients were zinc deficient based on their cellular zinc concentrations and zinc status was a better indicator of tumor burden and stage of disease in comparison to the overall nutritional status.
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